Research Program Overview

This ongoing study investigates how specific serum markers relate to the progression of cervical spondylotic myelopathy (CSM), a common condition causing spinal cord compression and neurological deficits in older adults. We are focusing on the neural cell adhesion molecule (NCAM) to understand its role in CSM stages and its potential to guide treatment decisions.

Our biomarker research program employs advanced molecular biology techniques and clinical correlation studies to identify, validate, and characterize protein markers that can serve as diagnostic, prognostic, and therapeutic monitoring tools for spine diseases. This approach represents a paradigm shift toward precision medicine in spine care, enabling personalized treatment strategies based on individual biomarker profiles.

Primary Research Areas

• Neural cell adhesion molecule (NCAM) analysis
• Cervical spondylotic myelopathy progression markers
• Serum biomarker identification and validation
• Disease stage correlation studies
• Treatment response monitoring
• Inflammatory cascade biomarkers
• Neurodegeneration protein markers
• Spinal cord compression indicators
• Prognostic biomarker development
• Precision medicine applications

Research Methodology

Our research program utilizes state-of-the-art proteomics and molecular biology techniques including enzyme-linked immunosorbent assays (ELISA), mass spectrometry, and multiplex protein analysis platforms. We employ rigorous study designs with appropriate controls and statistical power calculations to ensure reliable biomarker discovery and validation.

Clinical correlation studies involve comprehensive patient assessment including neurological examination, functional outcome measures, and advanced imaging studies. Longitudinal sample collection protocols enable tracking of biomarker changes over time and correlation with disease progression and treatment responses. We collaborate with clinical laboratories to establish standardized assay protocols for future clinical implementation.

Current Initiatives

NCAM in Cervical Myelopathy Study: Comprehensive analysis of neural cell adhesion molecule levels in patients with different stages of cervical spondylotic myelopathy to establish diagnostic and prognostic utility.

Biomarker-Guided Treatment Selection: Development of algorithms that incorporate biomarker profiles to optimize timing and selection of surgical versus conservative treatment approaches for spine disease patients.

Multi-Biomarker Panel Development: Creation of comprehensive biomarker panels that combine multiple protein markers to improve diagnostic accuracy and prognostic capability beyond single-marker approaches.